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Integrative Psychiatry

Psychedelics, Ego Dissolution, Fragmentation and the Role of Integration by Keith Kurlander, MA, LPC and Will Van Derveer, MD

By November 22, 2021March 6th, 2024No Comments

The correlation between psychedelic use and “psychological flexibility” has been recently explored in research by Robin Carhart-Harris [link HERE to article]. One of the potential benefits of psychedelics is to support increased psychological flexibility, potentially useful even to prevent psychological disorders. In theoretical discussion and research, ego dissolving experiences are a mechanism to loosen psychologically rigidity to promote ego structures that lend to more flexibility such as behavior change in accordance with personal values, remaining present to higher degrees of stimuli and emotional bandwidth, and the ability to adapt more often and quicker to new situations in one’s life.

Ego dissolution can be experienced as both blissful and relieving, as well as overwhelming and terrifying. Typically overwhelm and terror occur when there is an experience of the Self fragmenting from a sense of cohesion, and the self in disparate parts are trying to maintain a sense of identity as if it still exists. This experience of fighting for control and a normal reality can flood an individual in fear. 

With ketamine in particular, ego dissolution can reliably occur at higher doses. An experience of a fragmented, disturbing ego dissolution can happen in healthy individuals; however, it’s not common for these experiences to not return to a cohesive self within days with post integration sessions. However, clients with serious mental illness tend to be more prone to these more difficult experiences, partly due to having a less flexible self structure, which, in theory, can shatter into fragments when the boundary between self and other is loosened by a psychedelic experience. Therefore, clients that have more difficult mental health concerns will likely require more integration to return to seeing this as a positive, growth oriented experience.

Although this is not an experience to strive for with a client, it’s also not recommended to try and avoid at all costs. The benefits of altering a very rigid psychological structure after decades of other interventions not working can promote much greater healing with proper integration, if that were to occur. 

The question, “What is an ego dissolution state?” has yielded many opinions and is very relevant to working as a psychedelic therapist. Over the past 70 years of clinicians and researchers writing about the impacts that psychedelics appear to have on the self, many models have emerged for understanding ego dissolution states and the fragmented experiences of the clients that sometimes follow. 

A developmentally oriented therapist might understand a fragmented state as a pre-egoic state – akin to the concept that psychosis could be understood as a state similar to how an infant experiences reality. A parts-oriented therapist might consider the fragmented ego as an opportunity to integrate shards of a shattered self. A traumatologist might think of these as dissociative states as a response to, or recapitulating, a traumatic event. For example, states of fragmentation which repeatedly occurred during a (complex) traumatic early childhood, and which were suppressed over time, can and do re-emerge from behind the veil of ego defenses. A psychodynamic therapist might conceive of ego fragmentation as a primitive dissociative ego defense. 

Whatever the orientation, the first step when a client presents in a fragmented state after a psychedelic experience is psychological first aid to support a coalescence of the self-structure that has been temporarily lost. A variety of supportive approaches can be very helpful to clients during these times.

Relational support (versus isolation) is critical. It’s important to do in person integration sessions for these clients whenever possible. Calm, relaxed presence of another person can make all the difference. There is a delicate balance for someone who is severely fragmented between not talking about it too often throughout the day as that can exacerbate the experience, yet not feeling alone and knowing they share about it when they need to. More frequent follow-ups may be necessary as well. Therapeutic touch can be very helpful for grounding in such states, but as always should be approached with care and caution, without assuming anything and asking first. 

Another element of support is to diminish the risk of further overstimulation. The therapist should assume that many stimuli experienced by the client in such a state can feel overwhelming. This is especially true of the senses (e.g. sensory inputs are typically very heightened). This may include directing the client and caregivers toward lowering lighting, decreasing the exposure to chaotic or loud public environments, mindfulness around the type of music they are listening to, and slowing the pace of life as much as possible. 

Impulsivity is often heightened in these states, and clinicians would do well to anticipate such experiences and inquire directly about what impulses are arising for these clients. Big life decisions should be postponed. Clients can make rash life decisions during a period of a fragmented sense of self, only to realize when they return to a regulated, cohesive sense of self that big life changes were not necessary or even resulted in relational, financial, or personal self harm. The question of competency should be considered or even directly challenged with a client who plans to make an impulsive decision and refuses to wait until they are more whole again.

Foods that are perceived as supportive can be explored. Teaching the client mindfulness exercises can be very comforting. Nature is a powerful intervention during these times, such as lying flat on the earth and feeling the grounding energy. Returning to routine behaviors such as exercise, reading, etc. can also help coalesce the ego quicker from the familiarity. Weighted blankets, massage, yoga are also very effective at “grounding” individuals and helping them reintegrate into their bodies. Alternating hot and cold compresses on the back of the neck – a tool borrowed from dialectical behavioral therapy (DBT) – can also help. Because fragmentation blocks access to some of these resourcing strategies, a wide range of them should be proposed and discussed to personalize the integration process, as well as serving as a temporary external regulator with accountability check-ins and support.

Equally important is psychoeducation about what is likely occurring. Without a framework about what has happened, the client can remain extremely disoriented and terrified that this experience will never change. Many clients will wonder whether they have “broken their mind permanently” or “gone crazy.” It is important to educate the client from a theoretical perspective about what is occurring, why this isn’t a mistake or something that shouldn’t have happened, and how this temporary “loosening” of the mind can lead to a greater sense of flexibility and health in the cohesiveness that will arise on the other side. Reassuring the client that such states gradually resolve with integration or even sharing examples of other clients or yourself going through similar states can also feel deeply reassuring.

Written By:
Keith Kurlander MA, LPC
Will Van Derveer, MD

Sara Reed, MS, LMFT

Sara Reed is a Licensed Marriage and Family Therapist and CEO of Mind’s iHealth Solutions, a digital health company that provides evidence based and culturally responsible mental health services for underserved groups. As a mental health futurist and clinical researcher, Sara examines the ways culture informs the way we diagnose and treat mental illness. Sara’s prior research work includes participation as a study therapist in psychedelic therapy research at Yale University and the University of Connecticut’s Health Center. Sara was the first Black therapist to provide MDMA-assisted psychotherapy in a clinical trial and continues to engage in ongoing advocacy work around health equity in psychedelic medicine.

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Jeffrey Guss, MD is a psychiatrist, psychoanalyst, and researcher with specializations in psychoanalytic therapy and the treatment of substance use disorders. He was Co-Principal Investigator and Director of Psychedelic Therapy Training for the NYU School of Medicine’s study on psychedelic-assisted psychotherapy in the treatment of cancer-related existential distress, which was published in Journal of Psychopharmacology, 2016. He currently is a study therapist in the NYU study on Psychedelic-Assisted therapy in the treatment of Alcoholism, a collaborator with Yale University’s study on psychedelic-assisted therapy for Major Depressive Disorder and a study therapist with the MAPS (Multidisciplinary Association for Psychedelic Studies) study on treatment of Post Traumatic Stress Disorder with Psychedelic-Assisted Psychotherapy. 

Dr. Guss is interested in the integration of psychedelic therapies with contemporary psychoanalytic theory and has published in Studies in Gender and Sexuality and Psychoanalysis, Culture and Society. He has published (with Elizabeth Nielson, PhD) a paper on “the influence of therapists’ first had experience with psychedelics on psychedelic-assisted psychotherapy research and therapist training” in The Journal of Psychedelic Studies, August, 2018. He is an Instructor and Mentor with the California Institute of Integral Studies’ Center for Psychedelic Therapies and Supervisor in NYU’s Fellowship in Addiction Psychiatry. 

Dr. Guss maintains a private practice in New York City.

Will Van Derveer, MD

Will Van Derveer, MD is Co-Founder of Integrative Psychiatry Institute and Integrative Psychiatry Centers. Dr. Van Derveer was co-investigator on a phase 2 MAPS study of Psychedelic-assisted psychotherapy for treatment-resistant PTSD, and co-authored the publication of this study in 2018. He has also provided Psychedelic-assisted psychotherapy in two MAPS training studies. An active provider of KAP at his clinic in Boulder, CO, he has been teaching others KAP therapy for several years. Dr. Van Derveer contributed a chapter on mescaline in the 2021 "Handbook of Medical Hallucinogens" (edited by Charles Grob and Jim Grigsby). He is co-host of the Higher Practice Podcast.

Dr. Van Derveer regards unresolved emotional trauma as the most significant under-recognized root cause of psychiatric symptoms in integrative psychiatry practice, along with gut issues, hormone imbalances, inflammation, mitochondrial dysfunction, and other functional medicine challenges. He is trained in Somatic Experiencing, EMDR, Internal Family Systems, and other psychotherapy techniques. His current clinical passion is psychedelic-assisted psychotherapy, which he mentors interested doctors in providing. An avid meditator, he has been a meditation instructor since 2004.

For the past several years Dr. Van Derveer has taught psychiatrists and other psychiatric providers integrative psychiatry in a number of settings, including course directing the CU psychiatry residents’ course as well as with Scott Shannon and Janet Settle at the Psychiatry MasterClass.


Scott has been a student of consciousness since his honors thesis on that topic at the University of Arizona in the 1970s under the tutelage of Dr. Andrew Weil. Following medical school, Scott studied Jungian therapy and acupuncture while working as a primary care physician in a rural area for four years. Psychedelic-assisted psychotherapy became a facet of his practice before this medicine was scheduled in 1985. He then completed a psychiatry residency at Columbia program in New York. Scott studied cross-cultural psychiatry and completed a child/adolescent psychiatry fellowship at the University of New Mexico.

In 2010 he founded Wholeness Center in Fort Collins. This innovative clinic provides cross-disciplinary evaluation and care for all mental health concerns. Scott serves as a site Principal Investigator and therapist for the Phase III trial of psychedelic-assisted psychotherapy for PTSD sponsored by (MAPS). He has also published numerous articles about his research on (CBD) in mental health. Currently, Scott works extensively with psychedelic-assisted-psychotherapy. He lectures all over the world to professional groups interested in a deeper look at mental health issues, safer tools, and a paradigm-shifting perspective about transformative care.

Will Van Derveer, MD is co-founder of Integrative Psychiatry Institute (IPI), along with friend and colleague Keith Kurlander, MA. He co-created IPI as an expression of what he stands for. First, that anyone can heal, and second that we medical providers must embrace our own healing journeys in order to fully command our potency as healers.

Dr. Van Derveer spent the last 20 years innovating and testing a comprehensive approach to addressing psychiatric challenges which transcends the conventional model he learned in medical school at Vanderbilt University and residency at University of Colorado, while deeply engaging his own healing path.

He founded the Integrative Psychiatric Healing Center in in 2001 in Boulder, CO, where he currently practices. Dr. Van Derveer regards unresolved emotional trauma as the most significant root cause of psychiatric symptoms in integrative psychiatry practice, along with gut issues, hormone imbalances, inflammation, mitochondrial dysfunction, and other functional medicine challenges. He is trained in Somatic Experiencing, EMDR, Internal Family Systems, and other psychotherapy techniques. His current clinical passion is psychedelic-assisted psychotherapy, which he mentors interested doctors in providing. An avid meditator, he has been a meditation instructor since 2004.

For the past several years Dr. Van Derveer has taught psychiatrists and other psychiatric providers integrative psychiatry in a number of settings, including course directing the CU psychiatry residents’ course as well as with Scott Shannon and Janet Settle at the Psychiatry MasterClass. In addition to his clinical work and teaching, he was co-investigator in 2016 a Phase II randomized clinical trial, sponsored by the Multidisciplinary Association for Psychedelic Studies (MAPS). He continues to support this protocol, now in a Phase III clinical trial under break-through designation by FDA.

Dr. Van Derveer is a diplomate of the American Board of Integrative and Holistic Medicine (ABoIHM) since 2013, and he was board certified in the first wave of diplomates of the new American Board of Integrative Medicine (ABIM) in 2016.