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Integrative Psychiatry

When Your Brain Catches a Cold: Rethinking Mental “Illness” By Taking a Lesson from the Immune System

By November 13, 2024No Comments

The field of psychiatry, at least historically, has attempted to reduce the vast and colorful expressions of human experience to the binary categories of illness and health. What if it were more complex than that? As a physiologist-turned-therapist-in-training, I take a lesson from our immune system in the way that I approach diagnosis.

When a virus invades our bodies and we get sick, we often forget that the symptoms we are experiencing- headache, sore throat, upset stomach – are the product of our immune system fighting the pathogen and healing the body.

At IPI we teach that the mind-body-spirit is a whole and interconnected network that inherently carries all the tools to support wellness. Like the immune system, the psyche wants to heal and does its best to protect and safeguard the vulnerable parts of self. For example, “getting sick” or “having an illness” requires our own activated immune cells to stimulate an inflammatory response. In a similar way, might the symptoms we call “mental illness” be the result of mind-body-spirit doing its best to work through transformative change? 

When I think about labels like “mental illness,” I find myself questioning the disease model, the traditional medical model. While I do believe it can be helpful to have a name for what we are dealing with, I also wonder whether or not we might find compassion for the “illness.” What might be evolutionarily (or socially, or personally) adaptable about certain symptoms or behaviors, given the complex genetic, family history, and life experience that each of us embodies? 

One hypothesis, for example, is that depressive symptoms might have been adaptive across cycles of seasons and hunting/foraging during the Paleolithic era of human history. Depressive symptoms may have supported a period of withdrawal, rest, rejuvenation. Rumination would have been useful for reflection and planning new strategies between the community’s next pursuit. Perhaps this same evolutionary system gets activated during a period of helplessness, disconnection, and disengagement in the modern world. 

But the stress of the modern world doesn’t cycle like seasons; in fact it seems to keep accelerating. Our stress systems don’t get a chance to cycle off unless we force ourselves out of the overstimulating assault on our attention and power. Some questions to pose: how might depressive symptoms be trying to serve someone, when assessed with a particular person’s life history? What are they signaling, what is their function? Similar to parts work, I’m curious about the symptoms’ roles in safety, protection, and survival.

Sometimes, we know exactly when and where we acquired a pathogen, just like when we can link a traumatic event to our suffering. However, in other forms of trauma, it can be difficult to pinpoint the exact moment, and perhaps we’ve been worn down through a number of contextual factors,as in chronic stress. When our immune cells trigger inflammation, the process of “feeling ill” may be painful. Emotional “illness” is just as painful.

In some cases, healthy, necessary acute  inflammation doesn’t subside  and actually causes further damage (as we saw with COVID-19 hospitalizations as well as long COVID); similarly our psychospiritual defenses may not always resolve in a direction toward  health. It is possible that our attempts to heal, both physically and psychologically, get us stuck in a sort of chronic condition. When the body-mind-spirit’s response to insult (as with the immune dysfunction of long COVID) creates more imbalance, intervention may become necessary to support the system to restore balance. 

Trusting that our deeper selves are wired for wellbeing instills compassion for self and others, and empowers the body-mind-spirit in contrast to the conventional model of mental illness. In psychedelic-assisted therapy, the concept of innate wisdom of the self has been called the “inner healing intelligence.” Cultivating a deep connection with the inner healer, often more accessible during a psychedelic-assisted therapy session, can play a major role in building the foundation of a vibrant, meaningful life. Integration of mind-body-spirit parts can help open up the channels to the inner healing intelligence. 

I like to orient toward the internal trust that our networks of mind-body-spirit are doing the best that they can – given genetics, development, and lifestyle – to support themselves through struggle or overcoming trauma. Using this framework, perhaps “illness” may be redefined as the mind-body-spirit’s innate attempt to seek wholeness in response to an unsupportive environment. (I’ll take a note here to point out that a lot could be said about this from a social justice standpoint, such as social disparities in access to resources, discrimination, and stigma–but that’s for another blog). If we view the self as innately adaptive, flexible, and whole , then we can understand how trauma and diagnostic symptoms may be seen  as self-preservation mechanisms that somehow forgot to switch off.

Sara Reed, MS, LMFT

Sara Reed is a Licensed Marriage and Family Therapist and CEO of Mind’s iHealth Solutions, a digital health company that provides evidence based and culturally responsible mental health services for underserved groups. As a mental health futurist and clinical researcher, Sara examines the ways culture informs the way we diagnose and treat mental illness. Sara’s prior research work includes participation as a study therapist in psychedelic therapy research at Yale University and the University of Connecticut’s Health Center. Sara was the first Black therapist to provide MDMA-assisted psychotherapy in a clinical trial and continues to engage in ongoing advocacy work around health equity in psychedelic medicine.

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Jeffrey Guss, MD is a psychiatrist, psychoanalyst, and researcher with specializations in psychoanalytic therapy and the treatment of substance use disorders. He was Co-Principal Investigator and Director of Psychedelic Therapy Training for the NYU School of Medicine’s study on psychedelic-assisted psychotherapy in the treatment of cancer-related existential distress, which was published in Journal of Psychopharmacology, 2016. He currently is a study therapist in the NYU study on Psychedelic-Assisted therapy in the treatment of Alcoholism, a collaborator with Yale University’s study on psychedelic-assisted therapy for Major Depressive Disorder and a study therapist with the MAPS (Multidisciplinary Association for Psychedelic Studies) study on treatment of Post Traumatic Stress Disorder with Psychedelic-Assisted Psychotherapy. 

Dr. Guss is interested in the integration of psychedelic therapies with contemporary psychoanalytic theory and has published in Studies in Gender and Sexuality and Psychoanalysis, Culture and Society. He has published (with Elizabeth Nielson, PhD) a paper on “the influence of therapists’ first had experience with psychedelics on psychedelic-assisted psychotherapy research and therapist training” in The Journal of Psychedelic Studies, August, 2018. He is an Instructor and Mentor with the California Institute of Integral Studies’ Center for Psychedelic Therapies and Supervisor in NYU’s Fellowship in Addiction Psychiatry. 

Dr. Guss maintains a private practice in New York City.

Will Van Derveer, MD

Will Van Derveer, MD is Co-Founder of Integrative Psychiatry Institute and Integrative Psychiatry Centers. Dr. Van Derveer was co-investigator on a phase 2 MAPS study of Psychedelic-assisted psychotherapy for treatment-resistant PTSD, and co-authored the publication of this study in 2018. He has also provided Psychedelic-assisted psychotherapy in two MAPS training studies. An active provider of KAP at his clinic in Boulder, CO, he has been teaching others KAP therapy for several years. Dr. Van Derveer contributed a chapter on mescaline in the 2021 "Handbook of Medical Hallucinogens" (edited by Charles Grob and Jim Grigsby). He is co-host of the Higher Practice Podcast.

Dr. Van Derveer regards unresolved emotional trauma as the most significant under-recognized root cause of psychiatric symptoms in integrative psychiatry practice, along with gut issues, hormone imbalances, inflammation, mitochondrial dysfunction, and other functional medicine challenges. He is trained in Somatic Experiencing, EMDR, Internal Family Systems, and other psychotherapy techniques. His current clinical passion is psychedelic-assisted psychotherapy, which he mentors interested doctors in providing. An avid meditator, he has been a meditation instructor since 2004.

For the past several years Dr. Van Derveer has taught psychiatrists and other psychiatric providers integrative psychiatry in a number of settings, including course directing the CU psychiatry residents’ course as well as with Scott Shannon and Janet Settle at the Psychiatry MasterClass.


Scott has been a student of consciousness since his honors thesis on that topic at the University of Arizona in the 1970s under the tutelage of Dr. Andrew Weil. Following medical school, Scott studied Jungian therapy and acupuncture while working as a primary care physician in a rural area for four years. Psychedelic-assisted psychotherapy became a facet of his practice before this medicine was scheduled in 1985. He then completed a psychiatry residency at Columbia program in New York. Scott studied cross-cultural psychiatry and completed a child/adolescent psychiatry fellowship at the University of New Mexico.

In 2010 he founded Wholeness Center in Fort Collins. This innovative clinic provides cross-disciplinary evaluation and care for all mental health concerns. Scott serves as a site Principal Investigator and therapist for the Phase III trial of psychedelic-assisted psychotherapy for PTSD sponsored by (MAPS). He has also published numerous articles about his research on (CBD) in mental health. Currently, Scott works extensively with psychedelic-assisted-psychotherapy. He lectures all over the world to professional groups interested in a deeper look at mental health issues, safer tools, and a paradigm-shifting perspective about transformative care.

Will Van Derveer, MD is co-founder of Integrative Psychiatry Institute (IPI), along with friend and colleague Keith Kurlander, MA. He co-created IPI as an expression of what he stands for. First, that anyone can heal, and second that we medical providers must embrace our own healing journeys in order to fully command our potency as healers.

Dr. Van Derveer spent the last 20 years innovating and testing a comprehensive approach to addressing psychiatric challenges which transcends the conventional model he learned in medical school at Vanderbilt University and residency at University of Colorado, while deeply engaging his own healing path.

He founded the Integrative Psychiatric Healing Center in in 2001 in Boulder, CO, where he currently practices. Dr. Van Derveer regards unresolved emotional trauma as the most significant root cause of psychiatric symptoms in integrative psychiatry practice, along with gut issues, hormone imbalances, inflammation, mitochondrial dysfunction, and other functional medicine challenges. He is trained in Somatic Experiencing, EMDR, Internal Family Systems, and other psychotherapy techniques. His current clinical passion is psychedelic-assisted psychotherapy, which he mentors interested doctors in providing. An avid meditator, he has been a meditation instructor since 2004.

For the past several years Dr. Van Derveer has taught psychiatrists and other psychiatric providers integrative psychiatry in a number of settings, including course directing the CU psychiatry residents’ course as well as with Scott Shannon and Janet Settle at the Psychiatry MasterClass. In addition to his clinical work and teaching, he was co-investigator in 2016 a Phase II randomized clinical trial, sponsored by the Multidisciplinary Association for Psychedelic Studies (MAPS). He continues to support this protocol, now in a Phase III clinical trial under break-through designation by FDA.

Dr. Van Derveer is a diplomate of the American Board of Integrative and Holistic Medicine (ABoIHM) since 2013, and he was board certified in the first wave of diplomates of the new American Board of Integrative Medicine (ABIM) in 2016.